what is Weinreb AM Resin?
This abutment is advantageous for the assembly of peptide aldehydes and added carboxaldehydes. Following abatement of the Fmoc accumulation with 20% piperidine in DMF, acylation of the resin-bound methoxylamine is best accomplished application DIPCDI/HOAt or HATU/DIPEA activation. This after-effects in accumulation of a accurate Weinreb-type amide which can be either bargain to an aldehyde with LiAlH4 or broken with Grignard reagents to accord ketones.
Weinreb AM Resin is for in vitro analysis use only. Not for use in affection or ameliorative procedures.
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