What is an amino acids derivatives?
Bachem offers more than 3000 different amino acids and derivatives, resins, linkers and reagents for peptide synthesis from stock. In addition to the proteinogenic amino acids and derivatives, Bachem offers a vast range of unusual amino acids and derivatives. Our selection ranges form standard Fmoc and Boc amino acids for peptide synthesis to novel and unique protected building blocks offered exclusively by Bachem. We offer resins, building blocks, and reagents for solid phase peptide synthesis (SPPS) as well as suitably protected amino acid derivatives for the 'classical' solution peptide synthesis and for use as chiral educts in organic synthesis.
An amino acid derivative is a molecule that is generated using an amino acid as a starting point (precursor). For example, epinephrine is made out of tyrosine, in a synthesis reaction that involves 5 enzymes and several intermediate molecules. In the first step, an extra OH group is added to tyrosine (hydroxylation).
So in most cases, you can think of an amino acid derivative as the original amino acid plus or minus an extra chemical group.
Not all amino acids that are made in the cell will get incorporated into proteins. Some, like the example given above, will be used as building blocks or starter molecules for other biosynthesis pathways.