Immunogen:Synthetic phospho-peptide derived from the sequence of human Paxillin; sequence 87% identical to chicken
Description:Paxillin is a cytoskeletal adapter protein involved in the organization and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation, and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., actin, vinculin, Crk).
For research use only, not for diagnostic or therapeutic use.
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