PLC gamma 1 (phospho-Tyr783) Polyclonal Antibody

Specification:100 µL  
Purification:Peptide Affinity
Immunogen:Synthetic phospho-peptide derived from the sequence of human PLC¦Ã-1
Description:PLCgamma-1 (Phosphoinositide-specific phospholipase C) is a 135 kDa isoenzyme belonging to the PLC family of proteins that hydrolyzes phosphatidylinositol 4,5-biphosphate to produce the second messengers IP3 and diacylglycerol (DAG). PLCgamma-1 is ubiquitously expressed and modified by phosphorylation at two key tyrosine residues, Tyr783 and Tyr771, in response to non-receptor and receptor tyrosine kinase stimulation. Tyr783 phosphorylation is required for PLCgamma-1 activation, and regulates EGF-induced association of PLCgamma-1 with Akt.
For research use only, not for diagnostic or therapeutic use.

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