Cinque Terre

李姍

來源: 責任編輯: 發布:2017-04-11 點擊量:



李姍華中農業大學生命科學技術學院生物醫學中心教授博導


教育經歷

09/2003-07/2007 中國農業大學,生物科學,學士

09/2003-07/2007 中國農業大學,工商管理(生物技術企業經營管理),學士

09/2007-06/2013 北京生命科學研究所,生物化學與分子生物學,博士

07/2013-03/2015 北京生命科學研究所,博士后


工作經歷

01/2014-02/2017 湖北省十堰市太和醫院,感染與免疫性疾病研究所所長,中心實驗室主任,副教授,碩導

03/2017-至今 華中農業大學,生命科學與技術學院,生物醫學中心,教授,博導

本實驗室關注病原微生物感染與宿主先天性免疫分子機制的研究,李姍博士曾發現病原細菌以一種全新的蛋白質翻譯后修飾——精氨酸N-乙酰葡萄糖胺化修飾作用于死亡受體,從而抑制宿主先天性免疫反應(Li et al.,Nature, 2013),制備能特異性識別精氨酸N-乙酰葡萄糖胺化修飾的兔源單克隆抗體,為此全新修飾的研究打開了一扇大門(Pan & Li et al.,Angew. Chem. Int. Ed., 2014),受邀在細胞凋亡領域權威雜志Apoptosis雜志撰寫綜述(Luo et al., Apoptosis, 2015)。曾獲得吳瑞杰出生命科學獎。現主持國家自然科學基金面上項目,湖北省杰出青年人才基金項目,湖北省衛計委青年人才項目,湖北省教育廳創新團隊項目各一項。


研究方向

病原微生物與宿主互作,感染與免疫分子機制,死亡受體信號通路調節,新型蛋白質翻譯后修飾


研究生招生專業

生物化學與分子生物學,細胞生物學等

熱誠歡迎有志從事生命科學基礎研究的學生報考本實驗室碩士、博士,優秀的碩士研究生可直接轉博。

同時,本實驗室招聘科研助理,博士后,師資博士后若干名。有意者請將個人CV和代表性科研成果發送郵件至lishan@mail.hzau.edu.cn


聯系方式

郵件lishan@mail.hzau.edu.cn

辦公地點基因樓4樓433室


Scientific Publications

1. Luo J, Hu J, Zhang Y, Hu Q andLi S#. (2015) Hijacking of death receptor signaling by bacterial pathogen effectors.Apoptosis20:216-223.(Corresponding author)

2. Pan M*,Li S*,Li X, Shao F, Liu L, and Hu H. (2014) Synthesis and Specific Antibody generation of Glycopeptides with ArginineN-GlcNAcylation.Angewandte Chemie International Edition53(52):14517-14521.(Co-first author)

3.Li S*, Zhang L*, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S?, Shao F?. (2013) Pathogen blocks host death receptor signaling by arginine GlcNAcylation of death domains.Nature.501, 242-246.First authorThis work was featured inNature Reviews Microbiology

4. Lu Q,Li S, and Shao F. (2015) Sweet talk: protein glycosylation in bacterial interaction with the host.Trends in microbiology23(10):630-641.

5. Lu Q, Yao Q, Xu Y, Li L,Li S, Liu Y, Gao W, Niu M, Sharon M, Ben-Nissan G, Zamyatina A, Liu X, Chen S, Shao F (2014) An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis.Cell host & microbe16 (3):351-363.

6. Li C, Tu S, Wen S,Li S, Chang J, Shao F, Lei X.(2011) Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C.The Journal of Organic Chemistry, 76, 3566-70.

7. Cui J, Yao Q,Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F. (2010) Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family.Science, 329, 1215-8.

8. Gong YN, Wang X, Wang J, Yang Z,Li S, Yang J, Liu L, Lei X, Shao F. (2010) Chemical probing reveals insights into the signaling mechanism of inflammasome activation.Cell Research, 20, 1289-305.

9. Ge J, Xu H, Li T, Zhou Y, Zhang Z,Li S, Liu L, Shao F.(2009)ALegionellatype IV effector activates the NF-κB pathway by phosphorylating the IκB family of inhibitors.Proc. Natl. Acad. Sci., 106, 13725-30.

10. Wei B, Cai T, Zhang R, Li A, Huo N,Li S, Gu YQ, Vogel J, Jia J, Qi Y, Mao L.(2009) Novel microRNAs uncovered by deep sequencing of small RNA transcriptomes in bread wheat (Triticum aestivum L.) and Brachypodium distachyon (L.) Beauv.Funct Integr Genomics., 9, 499-511.

11. Mi S, Cai T, Hu Y, Chen Y, Hodges E, Ni F, Wu L,Li S, Zhou H, Long C, Chen S, Hannon G, Qi Y. (2008) Sorting of small RNAs intoArabidopsisArgonaute complexes is directed by the 5’ terminal nucleotide.Cell, 133: 116-127. This work was featured inCell133:25-26, 2008.

12. Zhao T, Li G, Mi S,Li S, Hannon G, Wang XJ*, Qi Y.* (2007). A complex system of small RNAs in the unicellular green algaChlamydomonas reinhardtii.Genes and Development,29, 1190-1203. This work was featured in:Cell129:1029, 2007;Genes and Development21: 1153-1156, 2007;Nature447: 5, 2007;Nature447: 518, 2007;Nature Review Genetics8: 406, 2007;ACS Chemical Biology2: 436-437, 2007.


Presentations

1. 2016, Nanhu International young scientist Forum, Wuhan, China (Talk)

2. 2016, Young investigator forum of Chinese society of immunology, Haikou, China (Talk)

3. 2015, CSH-Asia Conference on Bacterial Infection and Host Defense, Suzhou, China (Poster)

4. 2014, Three places on both sides Forum, Beijing, China (Talk)

5. 2013, CSH-Asia Conference on Bacterial Infection and Host Defense, Suzhou, China (Poster Award)

6. 2013, Ray Wu Symposium, Shanghai, China (Talk)

7. 2009, Drug innovation Forum, Tianjin, China (Talk)


Honors and Awards

1.Scientific elite Prize, 2015, Taihe hospital, Hubei university of medicine;

2.Ray Wu Prize, 2013, The Ray Wu Memorial Fund(Top scholarship for biomedical Ph.D. students in china);

3.Excellent Ph.D. Student Award, 2013,NIBS, Beijing, China;

4.First Prize poster (NIBS annual retreat), 2013,NIBS, Beijing, China;

5.Research Achievement Scholarship, 2012,China Agricultural University,Beijing, China;

6.Merit student Award, 2009-2010,China Agricultural University,Beijing, China;

7.Research Achievement Scholarship, 2010,China Agricultural University,Beijing, China;

8.Research Achievement Scholarship, 2009,China Agricultural University,Beijing, China;

9.Excellent poster (NIBS annual retreat), 2009,NIBS, Beijing, China;

10.Excellent Undergraduate Thesis Award, 2007,China Agricultural University,Beijing, China;

11.Excellent Student Cadre, 2005,China Agricultural University,Beijing, China;

12.Undergraduate scholarship,2003-2006,China Agricultural University,Beijing, China;


中國·湖北·武漢 南湖獅子山街一號430070 Tel:+86-27-87282101 E-mail:bio@mail.hzau.edu.cn

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