Cinque Terre

陳振夏

來源: 責任編輯: 發布:2016-09-20 點擊量:


陳振夏 博士 教授 博士生導師

Zhen-Xia Chen, Ph.D., Professor, PhD Supervisor

地址:基因樓418

Address: Gene Building 418, No.1 Shizishan Street Hongshan District, Wuhan, Hubei Province 430070

手機(Cell: 86-180 8611 3785

E-mail: zhen-xia.chen AT mail.hzau.edu.cn

研究方向 RESEARCH INTEREST

兩性間的表型差異主要由差異表達基因(即性別偏愛性基因)引起。性別偏愛性基因中包含大量的長鏈非編碼RNAlncRNA)基因。雖然已經發現一些性別偏愛性lncRNA具有調控性腺發育等重要功能,但是大部分仍然功能未知。本實驗室以往的研究證實利用高通量表達數據注釋非編碼功能元件的可靠性,并揭示性別相關驅動力對動物基因組中非編碼序列演化的作用。然而,盡管已發現一些性別偏愛性lncRNA可以調控性別發育,但尚有許多仍然功能未知。

目前本課題組的研究主要圍繞性別偏愛性lncRNA基因展開,運用高通量測序技術,結合遺傳學、分子生物學、發育生物學、演化生物學和生物信息學等手段,對斑馬魚、青鳉魚、雞、人等多物種基因組中性別偏愛性lncRNA基因進行系統地識別,并對其起源與演化機制、在性別發育中的功能以及對疾病發生的影響進行深入研究。其研究結果將有助于認識性別偏愛性lncRNA基因的功能,并對實施針對不同性別患者的個性化醫療方案這一目標的實現有重要的指導意義。

本實驗室真誠歡迎熱愛科學、擅長學習和樂于合作的本科生、研究生、博士生、博士后和其他科研人員的加入。

Sex dimorphism in phenotype is mainly caused by genes differentially expressed between sexes (called sex-biased genes). Many sex-biased genes are genes that encode long noncoding RNAs (lncRNA). Although some sex-biased lncRNAs have been found to regulate gonad development, the function of most lncRNAs are still unknown. Our previous study validated the transcriptome annotation of noncoding functional elements, and suggested the contribution of sex-related drives in the evolution of noncoding sequences in animal genomes. Although some sex-biased lncRNAs were found to be involved in sex development, the function of most sex-biased lncRNAs were still unknown. We thus focus on sex-biased lncRNAs, systematically identifying sex-biased lncRNAs in multiple animal species (including fruitfly, zebrafish, medaka, chicken, human, and etc.) with high-throughput sequencing techniques, and exploring their evolutionary mechanisms, functions in sex development, and potential effects on diseases. The implementation of our study will provide a solid foundation for revealing the function of sex-biased lncRNAs, and be important for precision medicine.

We sincerely welcome the participation of undergraduates, postgraduates, doctoral students, postdoctoral fellows and other scientific researchers who love science and are good at learning and cooperating.

教育經歷 (EDUCATION)

2006-2011 北京大學 生命科學技術學院生物信息中心 理學博士學位

Ph.D, Bioinformatics, Center for Bioinformatics, College of Life Sciences, Peking University, Beijing, China. Dissertation: Deficiency of X-linked inverted duplicates in Drosophila melanogaster and the underlying mechanisms. Mentor: Dr. Manyuan Long. 2006 - 2011

2002-2006 華中農業大學 生命科學技術學院 國家生命科學與技術人才培養基地 理學學士學位

Bachelor of Science, Biotechnology, National life science and technology talents training base, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China. 2002 - 2006

2003-2006 武漢大學 新聞傳播學院學院 新聞學 文學學士學位

Bachelor of Arts, Journalism, School of Journalism and Communication, Wuhan University, Wuhan, Hubei, China. 2003 - 2006

工作經歷 (WORK EXPERIENCE)

20016-至今 華中農業大學生命科學技術學院 教授

Professor, College of Life Sciences & Technology, Huazhong Agricultural University, Wuhan, China. 2016.9-Present

2011-2016 美國國立衛生研究院 消化、糖尿病、腎臟病研究所 博士后

Postdoc, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States. Mentor: Dr. Brian Oliver. 2011.9 - 2016.9

教學 (TEACHING COURSES)

生物信息學

Bioinformatics (http://www.icourses.cn/sCourse/course_6509.html)

生命科學導論

Introduction to Life sciences (http://www.icourse163.org/course/HZAU-1001967007)

所獲榮譽 (ACADEMIC AND PROFESSIONAL HONORS)


微課《達爾文與生物演化理論》獲“2017年全國高校生命科學類微課教學比賽三等獎

Third prize, National University Micro Lesson Teaching Competition (Life sciences), 2017.

青年教師講課競賽二等獎,生命科學技術學院,2017.

Second prize, Young Teachers’ Teaching Competition, College of Life Science and Technology, Huazhong Agricultural University, 2017.

杰出科學家獎,美國國立衛生研究院學生學者聯誼會,2016.

Distinguished Scientist Award, 2016 NIHCSSA Annual Symposium, Bethesda, Maryland, 2016.

女科學家旅行獎,第十屆國際基因組學大會,2015.

Women Scientists Travel Awards, The 10th International Conference on Genomics, Shenzhen, Guangzhou, China, 2015.

北京大學優秀博士學位論文,北京大學,2011.

Excellent Doctoral Dissertation, Peking University, Beijing, China, 2011.

北京大學優秀畢業生,北京大學,2011.

Outstanding Graduate, Peking University, Beijing, China, 2011.

湖北省大學生優秀科研成果二等獎,湖北省,2006.

2nd Place. University Students’ Outstanding Achievements in Scientific Research, Hubei Province, China, 2006.

發表文章 (PUBLICATIONS)

基因組演化和計算生物學科研論文

Research Reports on Genomic Evolution and Computational Biology

Luo ZH, Shi MW, Yang Z, Zhang HY*, Chen ZX*. pyMeSHSim: an integrative python package to realize biomedical named entity recognition, normalization and comparison (Submitted).

Shi MW#, Zhang NA#, Shi CP, Liu CJ, Luo ZH, Wang DY, Guo AY*, Chen ZX*. SAGD: a Comprehensive Sex-Associated Gene Database from Transcriptomes. Nucleic Acids Research. 2019.

Chen ZX*, Oliver B, Zhang YE, Gao G, Long M*. Expressed Structurally-stable Inverted Duplicates in Mammalian Genomes as Functional Noncoding Elements. Genome Biology and Evolution. 9(4):981–992 (2017).

Lin Y, Chen ZX, Oliver B, Harbison ST*. Microenvironmental Gene Expression Plasticity Among Individual Drosophila melanogaster. G3-Genes Genomes Genetics. 6: 4197-4210 (2016).

Lin Y, Golovnina K, Chen ZX, Lee HN, Negron YL, Sultana H, Oliver B, Harbison ST*. Comparison of normalization and differential expression analyses using RNA-Seq data from 726 individual Drosophila melanogaster. BMC Genomics 17: 28 (2016).

Chen ZX & Oliver B*. X Chromosome and Autosome Dosage Responses in Drosophila melanogaster Heads. G3-Genes Genomes Genetics. 5(6):1057-63 (2015).

Clough E, Jimenez E, Kim YA, Whitworth C*, Neville MC, Hempel L, Pavlou H, Chen ZX, Sturgill D, Dale R, Smith HE, Przytycka TM*, Goodwin SF*, Doren MV*, Oliver B*. Sex- and Tissue-specific Functions of Drosophila Doublesex Transcription Factor Target Genes.  Dev. Cell. 31(6):761-73 (2014).

Chen ZX#, Sturgill D#, Qu J, Jiang H, Park S, Boley N, Suzuki AM, Fletcher AR, Plachetzki DC, FitzGerald PC, Artieri CG, Atallah J, Barmina O, Brown JB, Blankenburg KP, Clough E, Dasgupta A, Gubbala S, Han Y, Jayaseelan JC, Kalra D, Kim YA, Kovar CL, Lee SL, Li M, Malley JD, Malone JH, Mathew T, Mattiuzzo NR, Munidasa M, Muzny DM, Ongeri F, Perales L, Przytycka TM, Pu LL, Robinson G, Thornton RL, Saada N, Scherer SE, Smith HE, Vinson C, Warner CB, Worley KC, Wu YQ, Zou X, Cherbas P, Kellis M, Eisen MB, Piano F, Kionte K, Fitch DH, Sternberg PW, Cutter AD, Duff MO, Hoskins RA, Graveley BR, Gibbs RA, Bickel PJ, Kopp A, Carninci P, Celniker SE, Oliver B*, Richards S. Comparative analysis of the D.melanogaster modENCODE transcriptome annotation. Genome Research. 24:1209-23 (2014).

Chen ZX*, Golovnina K, Sultana H, Kumar S, Oliver B. Transcriptional effects of gene dose reduction. Biology of Sex Differences, 5(1): 5 (2014).

Chen ZX, Zhang YE, Vibranovski M, Luo J, Gao G*, Long M*. Deficiency of X-linked inverted duplicates with male-biased expression and the underlying evolutionary mechanisms in the Drosophila genome. Mol Biol Evol. 28:2823-2832 (2011).

發表數據集

Data

Golovnina K, Chen ZX, Lin Y, Sultana H, Oliver B, Harbison S, 2015. mRNA-Seq data of whole female/male individuals from 16 inbred Drosophila melanogaster DGRP lines. Gene Expression Omnibus GSE60314.

Chen ZX, Oliver B. 2015. mRNA-Seq of female, male, and sex-transformed Drosophila melanogaster heads from flies heterozygous for deletions on chromosome X and 3L. Gene Expression Omnibus GSE60571.

Chen ZX, Oliver B. 2015. CAGE-Seq of gonads and carcasses from D. melanogaster and D. pseudoobscura. Gene Expression Omnibus GSE66284.

Sturgill D, Chen ZX, Kopp A, Richards S, Oliver B. 2013. mRNA-Seq of whole adult females and males, and mixed sex embryos, from multiple Drosophila species. Gene Expression Omnibus GSE43321.

Oliver B, Chen ZX, Sturgill. 2013. New Drosophila pseudoobscura RNA-Seq coverage data. FlyBase. http://flybase.org/cgi-bin/gbrowse/dpse/

發表社科文章

Research Report on Social sciences

龍漫遠,陳振夏. 達爾文和他改變的世界.科學文化評論. 6(4): 13-26 (2009).

陳振夏. 大學生課外活動參與狀況調查與研究.華中農業大學學報(社科版), 5,6: 118-121 (2005).

其他發表文章

Other Publications

陳振夏. 果蠅的祖先天生雙性戀?牛頓科學世界, (2010)

陳振夏. Y染色體少了,男人要沒了?南都周刊, (2009)

陳振夏. 興趣不是奢侈品. ——從喜歡花鳥蟲魚的日本皇子說起.科學時報, (2008).

Chen ZX. Genomics: A promising investment opportunity. BiotechBlog (2014).

陳振夏. 《在燕園留下的第一次》. 霍曉丹 編著. 《絢彩燕園青春北大——60位北大優秀畢業生的校園記憶》,北京大學出版社(2011).

本實驗室動態(LAB NEWS

實驗室博客:http://blog.sciencenet.cn/u/chenzhenxia119

微信公眾號“EvoDevo好好玩,本實驗室創建,內容包括演化發育基因組學領域的文獻推薦、學習資源、技術博客、學術活動等。

QQ討論群JC Bioinformatics653435863),本實驗室創建,面向全校生信愛好者,進行生物信息學技術交流和資源分享,并發布生物信息學興趣小組線下活動通知。


中國·湖北·武漢 南湖獅子山街一號430070 Tel:+86-27-87282101 E-mail:bio@mail.hzau.edu.cn

CopyRight?2001-2010華中農業大學生命科學技術學院 版權所有 技術支持:現代教育技術中心

365彩票-安全购彩