Cinque Terre


來源: 責任編輯: 發布:2016-09-20 點擊量:

陳振夏 博士 教授 博士生導師

Zhen-Xia Chen, Ph.D., Professor, PhD Supervisor


Address: Gene Building 418, No.1 Shizishan Street Hongshan District, Wuhan, Hubei Province 430070

手機(Cell: 86-180 8611 3785

E-mail: zhen-xia.chen AT





Sex dimorphism in phenotype is mainly caused by genes differentially expressed between sexes (called sex-biased genes). Many sex-biased genes are genes that encode long noncoding RNAs (lncRNA). Although some sex-biased lncRNAs have been found to regulate gonad development, the function of most lncRNAs are still unknown. Our previous study validated the transcriptome annotation of noncoding functional elements, and suggested the contribution of sex-related drives in the evolution of noncoding sequences in animal genomes. Although some sex-biased lncRNAs were found to be involved in sex development, the function of most sex-biased lncRNAs were still unknown. We thus focus on sex-biased lncRNAs, systematically identifying sex-biased lncRNAs in multiple animal species (including fruitfly, zebrafish, medaka, chicken, human, and etc.) with high-throughput sequencing techniques, and exploring their evolutionary mechanisms, functions in sex development, and potential effects on diseases. The implementation of our study will provide a solid foundation for revealing the function of sex-biased lncRNAs, and be important for precision medicine.

We sincerely welcome the participation of undergraduates, postgraduates, doctoral students, postdoctoral fellows and other scientific researchers who love science and are good at learning and cooperating.


2006-2011 北京大學 生命科學技術學院生物信息中心 理學博士學位

Ph.D, Bioinformatics, Center for Bioinformatics, College of Life Sciences, Peking University, Beijing, China. Dissertation: Deficiency of X-linked inverted duplicates in Drosophila melanogaster and the underlying mechanisms. Mentor: Dr. Manyuan Long. 2006 - 2011

2002-2006 華中農業大學 生命科學技術學院 國家生命科學與技術人才培養基地 理學學士學位

Bachelor of Science, Biotechnology, National life science and technology talents training base, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China. 2002 - 2006

2003-2006 武漢大學 新聞傳播學院學院 新聞學 文學學士學位

Bachelor of Arts, Journalism, School of Journalism and Communication, Wuhan University, Wuhan, Hubei, China. 2003 - 2006


20016-至今 華中農業大學生命科學技術學院 教授

Professor, College of Life Sciences & Technology, Huazhong Agricultural University, Wuhan, China. 2016.9-Present

2011-2016 美國國立衛生研究院 消化、糖尿病、腎臟病研究所 博士后

Postdoc, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States. Mentor: Dr. Brian Oliver. 2011.9 - 2016.9



Bioinformatics (


Introduction to Life sciences (



Third prize, National University Micro Lesson Teaching Competition (Life sciences), 2017.


Second prize, Young Teachers’ Teaching Competition, College of Life Science and Technology, Huazhong Agricultural University, 2017.


Distinguished Scientist Award, 2016 NIHCSSA Annual Symposium, Bethesda, Maryland, 2016.


Women Scientists Travel Awards, The 10th International Conference on Genomics, Shenzhen, Guangzhou, China, 2015.


Excellent Doctoral Dissertation, Peking University, Beijing, China, 2011.


Outstanding Graduate, Peking University, Beijing, China, 2011.


2nd Place. University Students’ Outstanding Achievements in Scientific Research, Hubei Province, China, 2006.



Research Reports on Genomic Evolution and Computational Biology

Luo ZH, Shi MW, Yang Z, Zhang HY*, Chen ZX*. pyMeSHSim: an integrative python package to realize biomedical named entity recognition, normalization and comparison (Submitted).

Shi MW#, Zhang NA#, Shi CP, Liu CJ, Luo ZH, Wang DY, Guo AY*, Chen ZX*. SAGD: a Comprehensive Sex-Associated Gene Database from Transcriptomes. Nucleic Acids Research. 2019.

Chen ZX*, Oliver B, Zhang YE, Gao G, Long M*. Expressed Structurally-stable Inverted Duplicates in Mammalian Genomes as Functional Noncoding Elements. Genome Biology and Evolution. 9(4):981–992 (2017).

Lin Y, Chen ZX, Oliver B, Harbison ST*. Microenvironmental Gene Expression Plasticity Among Individual Drosophila melanogaster. G3-Genes Genomes Genetics. 6: 4197-4210 (2016).

Lin Y, Golovnina K, Chen ZX, Lee HN, Negron YL, Sultana H, Oliver B, Harbison ST*. Comparison of normalization and differential expression analyses using RNA-Seq data from 726 individual Drosophila melanogaster. BMC Genomics 17: 28 (2016).

Chen ZX & Oliver B*. X Chromosome and Autosome Dosage Responses in Drosophila melanogaster Heads. G3-Genes Genomes Genetics. 5(6):1057-63 (2015).

Clough E, Jimenez E, Kim YA, Whitworth C*, Neville MC, Hempel L, Pavlou H, Chen ZX, Sturgill D, Dale R, Smith HE, Przytycka TM*, Goodwin SF*, Doren MV*, Oliver B*. Sex- and Tissue-specific Functions of Drosophila Doublesex Transcription Factor Target Genes.  Dev. Cell. 31(6):761-73 (2014).

Chen ZX#, Sturgill D#, Qu J, Jiang H, Park S, Boley N, Suzuki AM, Fletcher AR, Plachetzki DC, FitzGerald PC, Artieri CG, Atallah J, Barmina O, Brown JB, Blankenburg KP, Clough E, Dasgupta A, Gubbala S, Han Y, Jayaseelan JC, Kalra D, Kim YA, Kovar CL, Lee SL, Li M, Malley JD, Malone JH, Mathew T, Mattiuzzo NR, Munidasa M, Muzny DM, Ongeri F, Perales L, Przytycka TM, Pu LL, Robinson G, Thornton RL, Saada N, Scherer SE, Smith HE, Vinson C, Warner CB, Worley KC, Wu YQ, Zou X, Cherbas P, Kellis M, Eisen MB, Piano F, Kionte K, Fitch DH, Sternberg PW, Cutter AD, Duff MO, Hoskins RA, Graveley BR, Gibbs RA, Bickel PJ, Kopp A, Carninci P, Celniker SE, Oliver B*, Richards S. Comparative analysis of the D.melanogaster modENCODE transcriptome annotation. Genome Research. 24:1209-23 (2014).

Chen ZX*, Golovnina K, Sultana H, Kumar S, Oliver B. Transcriptional effects of gene dose reduction. Biology of Sex Differences, 5(1): 5 (2014).

Chen ZX, Zhang YE, Vibranovski M, Luo J, Gao G*, Long M*. Deficiency of X-linked inverted duplicates with male-biased expression and the underlying evolutionary mechanisms in the Drosophila genome. Mol Biol Evol. 28:2823-2832 (2011).



Golovnina K, Chen ZX, Lin Y, Sultana H, Oliver B, Harbison S, 2015. mRNA-Seq data of whole female/male individuals from 16 inbred Drosophila melanogaster DGRP lines. Gene Expression Omnibus GSE60314.

Chen ZX, Oliver B. 2015. mRNA-Seq of female, male, and sex-transformed Drosophila melanogaster heads from flies heterozygous for deletions on chromosome X and 3L. Gene Expression Omnibus GSE60571.

Chen ZX, Oliver B. 2015. CAGE-Seq of gonads and carcasses from D. melanogaster and D. pseudoobscura. Gene Expression Omnibus GSE66284.

Sturgill D, Chen ZX, Kopp A, Richards S, Oliver B. 2013. mRNA-Seq of whole adult females and males, and mixed sex embryos, from multiple Drosophila species. Gene Expression Omnibus GSE43321.

Oliver B, Chen ZX, Sturgill. 2013. New Drosophila pseudoobscura RNA-Seq coverage data. FlyBase.


Research Report on Social sciences

龍漫遠,陳振夏. 達爾文和他改變的世界.科學文化評論. 6(4): 13-26 (2009).

陳振夏. 大學生課外活動參與狀況調查與研究.華中農業大學學報(社科版), 5,6: 118-121 (2005).


Other Publications

陳振夏. 果蠅的祖先天生雙性戀?牛頓科學世界, (2010)

陳振夏. Y染色體少了,男人要沒了?南都周刊, (2009)

陳振夏. 興趣不是奢侈品. ——從喜歡花鳥蟲魚的日本皇子說起.科學時報, (2008).

Chen ZX. Genomics: A promising investment opportunity. BiotechBlog (2014).

陳振夏. 《在燕園留下的第一次》. 霍曉丹 編著. 《絢彩燕園青春北大——60位北大優秀畢業生的校園記憶》,北京大學出版社(2011).

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